‘Ceravac’- India’s first native Vaccine for Cervical Cancer

Cervical Cancer's vaccine

The maiden Indian made vaccine ‘Ceravac’ for cervical cancer is to be launched . The Department of Biotechnology and Serum Institute, Pune have developed a cervical cancer’s vaccine which will be affordable at the cheap rate of Rs 200 to 400 per dose. Ceravac is an indigenously developed cervical cancer vaccine caused by the human-papilloma-virus(HPV). Some of Indian Initiatives are National Cancer Grid and National Programme for Prevention Control of Cancer, Diabetes, Cardiovascular Diseases and Stroke (NPCDS).

What is cancer?

It is a large group of diseases that can start in almost any organ or tissue of the body when abnormal cells grow uncontrollably, go beyond their usual boundaries to invade adjoining parts of the body and/or spread to other organs. The latter process is called metastasizing and is a major cause of death from cancer. A neoplasm and malignant tumor are other names of cancer. World Cancer Day is organized by UICC and celebrated on 4th February.

Cervical Cancer is the second most frequent cancer among women in India. About 5% of women are estimated to have cervical HPV-16/18 infection. 6lakh women diagnosed with cervical cancer in 2020. 1.4lakh women died of the diseases worldwide.

Human Papilloma Virus- the main cause of Cervical Cancer

HPV is the most common viral infection of the reproductive tract. There are more than 100 types of HPV. More than 40 types of HPV are spread through direct sexual contact. Two of them cause genital warts, while about a dozen of HPV cause cancer’s like cervical, anal, penile, vaginal etc. More than 90% of cervical cancer cases are caused by HPVs.

Cervical Cancer cause and prevention
From- Google | By- The Indian Express

Types of HPV Vaccines

GardasilIt protects against HPV 16,18,6 and 11.
CervarixIt protects against HPV 16 and 18 only
Gardasil9It protects against nine strains of HOV
These vaccines prevent cervical cancer in women and girls who have not yet been exposed to the virus.

Two HPV vaccines are available in the private market currently, both made by foreign companies: Gardasil by Merck and Cervarix by GlaxoSmithKline. But they are quite expensive, hence not affordable by people of low and middle income countries.

Ceravac – Vaccine for cervical cancer

Announcing the scientific completion of the vaccine that took more than a decade to develop. The central government said that around 2000 volunteers had participated for the clinical trials in the country. Pune-based Serum India developed Ceravac in collaboration with the government’s biotechnology department. Three doses schedule for 15-26 year olds and two doses for 9-14 year olds. It is based on virus like particle technology.

“Initially, the vaccine will be supplied to the government programme and then from next year onwards, some private partners may also be involved,” said Serum India CEO Adar Poonawala

Work started in September 2011 and the vaccine was approved by India’s drug regulatory in July this year.

“Partnerships between private-public are becoming very important in such researches, this co-creation is what that’s going to make all the difference in the world,” said Rajesh Gokhale, secretary in the department of biotechnology.

Covid-19 has also raised awareness about preventive healthcare and Ceravac will help such efforts. Ceravac, which is based on Virus-like-particle (VLP) platform technology, has demonstrated a robust antibody response nearly 1000 times higher than the baseline against all targeted HPV types and in all dose and age groups. Ceravac is quadrivalent HPV vaccine which work against HPV types 6,11 16, 18.

It means the cervical cancer vaccine protects against four different strains of the HPV and approximately give coverage against 90% of HPV prevalent in the developing world.

Sodhi Gautam

Sodhi Gautam

84 thoughts on “‘Ceravac’- India’s first native Vaccine for Cervical Cancer

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